期刊
GASTROENTEROLOGY
卷 142, 期 7, 页码 1447-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2012.03.006
关键词
Mouse Model; Liver Disease; Virology; Immunity
资金
- Helmholtz Alliance for Immunotherapy [HA-202]
- German Research Foundation [SFB 670, TR57, 704, SFB 576]
- European Research Council [261317]
- BONFOR
- European Research Council (ERC) [261317] Funding Source: European Research Council (ERC)
Studies of mechanisms responsible for the persistence of hepatitis B virus (HBV) infection have been hindered by a lack of appropriate animal models. HBV genomes can be delivered to livers of mice using hydrodynamic injection or high doses of an adenoviral vector; these lead to clearance of HBV. We found that infection of immunocompetent mice with low doses of an adenoviral vector resulted in persistent HBV infection; the mice neither underwent seroconversion to production of antibodies against HBV nor developed a strong HBV-specific effector T-cell response. As in patients with chronic HBV infection, DNA vaccination failed to generate T cells that cleared infection. This model of persistent HBV infection could be used to study the pathogenesis of chronic HBV infection and develop new therapeutic strategies.
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