期刊
JOURNAL OF UROLOGY
卷 194, 期 2, 页码 556-562出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.juro.2015.02.2941
关键词
urinary bladder; carcinoma; lymphocytes; tumor infiltrating; antigens, CD8; prognosis
资金
- National Natural Science Foundation of China [U1301221, 81472384, 81372729, 81372883, 81272808, 81172431, 81101935, 81402106]
- Guangdong Province Natural Scientific Foundation [S2013020012671, 07117336, 10151008-901000024]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130171110073]
- Sun Yat-Sen University Clinical Research 5010 Program [2007018]
- Elite Young Scholars Program of Sun Yat-Sen Memorial Hospital [J201401]
- National Clinical Key Specialty Construction Project (Department of Urology)
- National Clinical Key Specialty Construction Project (Department of Oncology)
- Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes
- Sun-Yat-Sen University [KLB09001]
- China Postdoctoral Science Foundation [2014M562241]
Purpose: CD8(+) TILs at different tumor sites have diverse clinical attributes, which might result from distinct tumor microenvironments that promote differentiation into distinct subsets. However, only a few markers have been identified that can define CD8(+) T-cell subsets. CD103 is a marker of tissue resident memory CD8(+) T cells. In this retrospective study we investigated the cellular source and clinical significance of CD103 expression in urothelial cell carcinoma of bladder tissues in situ. Materials and Methods: Immunohistochemistry and immunofluorescence were used to identify the cellular source of CD103 in bladder urothelial cell carcinoma tissues. Kaplan-Meier analysis and Cox proportional hazards regression models were applied to estimate overall and recurrence-free survival in 302 patients with bladder urothelial cell carcinoma. Results: CD8(+) T cells but not natural killer cells accounted for most CD103 expressing cells in bladder urothelial cell carcinoma tissues. Notably CD103(+) cells were predominantly located in intratumor regions rather than in associated stroma (p < 0.0001). The density of intratumor CD103(+) TILs was inversely associated with tumor size (p < 0.0001) and could represent a favorable prognostic predictor of overall and recurrence-free survival (p = 0.002 and 0.011, respectively). Moreover, intratumor CD103(+) TILs were positively associated with the expression of cognate ligand E-cadherin in intratumor regions of bladder urothelial cell carcinoma tissues (p = 0.008). Conclusions: Our findings suggest that CD8(+) T cells might have a significant role in tumor immunity by expressing CD103 in intratumor regions of bladder urothelial cell carcinoma tissues. Intratumor CD103(+) TILs could potentially serve as a prognostic marker in patients with bladder urothelial cell carcinoma.
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