期刊
FUTURE VIROLOGY
卷 7, 期 9, 页码 885-899出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FVL.12.81
关键词
A beta; Alzheimer's disease; amyloid precursor protein; APP; cerebrospinal fluid; CNS; encephalitis; fast axonal transport; HSV; senile plaques; trigeminal ganglion; trigeminal nucleus
类别
资金
- NIGMS [P5OGM08273, GM47368, NINDS NS046810, NS062184]
- Harvey Family Endowment
HSV, a neurotropic virus, travels within neuronal processes by fast axonal transport. During neuronal infection HSV travels retrograde from the sensory nerve terminus to the neuronal cell body, where it replicates or enters latency. During replication HSV travels anterograde from the cell body to the nerve terminus. Postmortem studies find a high frequency of HSV DNA in the trigeminal ganglia as well as the brain. Studies correlating HSV with Alzheimer's disease (AD) have been controversial. Here we review clinical evidence supporting such a link. Furthermore, the author describes experimental data showing physical interactions between nascent HSV particles and host transport machinery implicated in AD. The author concludes that the complexity of this relationship has been insufficiently explored, although the relative ease and nontoxicity of a potential anti-HSV treatment for AD demands further study.
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