期刊
FUTURE ONCOLOGY
卷 10, 期 15, 页码 2423-2427出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.14.159
关键词
gastrointestinal stromal tumor; imatinib; metastatic gastrointestinal stromal tumor; pleural effusion; toxicity
类别
Gastrointestinal stromal tumors are rare malignancies characterized by c-kit and PDGFR- mutations targeted by imatinib. Pleural effusion is a very rare side effect of imatinib treatment. A 65-year-old female with metastatic gastrointestinal stromal tumor developed electrolyte imbalance, severe peripheral edema and progressively worsening dyspnea 2 months after starting imatinib. Having excluded cardiovascular and pulmonary disorders, imatinib was discontinued and prednisone 25 mg orally daily was begun. The patient's condition improved substantially over the next 48 h with a progressive decrease in dyspnea and a reduction in pleural effusion and peripheral edema. All side effects had resolved within 1 month. In view of the partial response obtained, the patient re-started imatinib after a 1-week interruption. Prednisone was maintained and there was no further toxicity.
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