期刊
FUTURE ONCOLOGY
卷 9, 期 9, 页码 1353-1364出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.13.84
关键词
anti-tumor effect; apigenin; glucose uptake; GLUT-1; head and neck cancer; PI3K; Akt pathway
类别
资金
- Health Department of Zhejiang Province [2010KYA062, 2009B042]
- National Natural Science Foundation of China [81172562]
Apigenin, a natural phytoestrogen flavonoid, has potential biological effects, including antioxidative, anti-inFLammatory and anticancer activities. The mechanisms of anticancer activities of apigenin are unknown. Some studies have found that apigenin inhibits GLUT-1 mRNA and protein expression in cancer cells. Thus, we hypothesized that apigenin exerts similar effects on head and neck cancers through its inhibition of GLUT-1 expression. In this article, we review the anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers. In addition, we describe the current state of knowledge about the relationship between apigenin and GLUT-1 expression in head and neck cancers.
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