期刊
FUTURE ONCOLOGY
卷 8, 期 1, 页码 29-36出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FON.11.128
关键词
cancer surgery; compartment; embryology; ontogenetic anatomy; tumor invasion
类别
资金
- University of Leipzig, Germany
- Leipzig School of Radical Pelvic Surgery
The pathophysiologic process of local tumor spread is regarded as an isotropic infiltration of microscopic extensions of the malignant lesion irrespective of tissue boundaries. By contrast, the ontogenetic compartment theory states that malignant solid tumors are locally confined, for a relatively long phase during their natural course, to a permissive compartment derived from a common primordium in embryonic development. Tumor permeation is isotropic within the permissive ontogenetic compartment, but it is suppressed at the compartment borders. The validity of the ontogenetic compartment theory has been shown for cancer of the rectum and of the female lower genital tract. It is hypothesized that ontogenetic compartment resection, the translation of the theory into cancer surgery, holds a great potential to improve oncologic treatment results.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据