期刊
FUTURE ONCOLOGY
卷 8, 期 7, 页码 803-817出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FON.12.76
关键词
bone; breast cancer; metastasis; parathyroid hormone-related protein; premetastatic niche; prostate cancer; PTHrP
类别
资金
- Department of Defense Prostate Cancer Research Program award [W81XWH-10-1-0546]
- National Cancer Institute award [P01-CA093900]
PTHrP, identified during the elucidation of mediators of malignancy-induced hypercalcemia, plays numerous roles in normal physiology as well as pathological conditions. Recent data support direct functions of PTHrP in metastasis, particularly from tumors with strong bone tropism. Bone provides a unique metastatic environment because of mineralization and the diverse cell populations in the bone marrow. PTHrP is a key regulator of tumor-bone interactions and regulates cells in the bone microenvironment through proliferative and prosurvival activities that prime the 'seed' and the 'soil' of the metastatic lesion. This review highlights recent findings regarding the role of PTHrP in skeletal metastasis, including direct actions in tumor cells, as well as alterations in the bone microenvironment and future perspectives involving the potential roles of PTHrP in the premetastatic niche, and tumor dormancy.
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