期刊
FUTURE ONCOLOGY
卷 8, 期 9, 页码 1157-1165出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FON.12.93
关键词
cell lines; electronic nose; machine olfaction; olfactory detection; prostate cancer; volatile organic compounds
类别
资金
- University of Eastern Finland
- Tampere University Hospital [9M070, 9M048, 9N035]
- Elna Kaarina Savolainen's Cancer Research Fund
- Tampere Tuberculosis Foundation
Aim: To determine whether an electronic nose can differentiate cultured nonmalignant and malignant prostatic cells from each other and whether the smell print is secreted to the surrounding medium. Materials & methods: Prostatic nonmalignant (EP-156T and controls) and malignant (LNCaP) cell lines, as well as conditioned and unconditioned media, were collected. The smell prints of the samples were analyzed by a ChemPro (R) 100 electronic nose device. The data were normalized and dimension reduction was conducted. The samples were classified and misclassification rates were calculated. Results: The electronic nose differentiated the nonmalignant and malignant cell lines from each other, achieving misclassification rates of 2.9-3.6%. Cells did not differ from the conditioned medium but differed from the unconditioned medium (misclassification rates: 0.0-25.6%). Conclusion: Malignant and nonmalignant prostatic cell lines have distinct smell prints. Prostatic cancer cells seem to modify the smell print of their medium.
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