期刊
FUTURE ONCOLOGY
卷 7, 期 9, 页码 1045-1055出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FON.11.74
关键词
biomarker; miRNA; miRNA expression; non-small-cell lung cancer; personalized medicine
类别
miRNAs play an important role in the regulation of a wide assortment of cellular processes by sequestering target mRNAs and inhibiting translation of the proteins that they encode. Multiple miRNAs can regulate single mRNA molecules and, alternatively, a single miRNA can act on a number of mRNA targets. Dysfunctional miRNAs are commonly found in a variety of solid cancers and are attractive candidates for next-generation therapeutics. This article highlights miRNA signatures proposed for lung cancer classification and diagnosis, chemo-and radio-therapy resistance, metastasis and prediction of treatment outcome and survival.
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