期刊
FUTURE ONCOLOGY
卷 5, 期 1, 页码 117-130出版社
FUTURE MEDICINE LTD
DOI: 10.2217/14796694.5.1.117
关键词
mitochondria; p53; reactive oxygen species; skin cancer; ultraviolet radiation
类别
资金
- NCI NIH HHS [R01 CA073599-09A1, R01 CA049797, R01 CA049797-18, R01 CA073599, R01 CA139843, R01 CA139843-01] Funding Source: Medline
p53 has been referred to as the 'guardian of the genome' because of its role in protecting the cell from DNA damage. p53 performs its duties by regulating cell-cycle progression and DNA repair and, in cases of irreparable DNA damage, by executing programmed cell death, Mitochondria are an important target of transcription-dependent and -independent actions of p53 to carry out the apoptotic function, However, increasing evidence suggests that p53 activity is regulated by mitochondria. Cellular insults that alter mitochondrial function can have important consequences on p53 activity. In light of these new findings, the following review focuses on p53/mitochondria connections, in particular how reactive oxygen species generated at mitochondria regulate p53 activity. A better understanding of the mechanisms by which mitochondria regulate p53 may have an impact on our understanding of the development and progression of many diseases, especially cancer.
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