4.4 Article

Targeting the mTOR pathway using deforolimus in cancer therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

Role of mTOR in anticancer drug resistance: Perspectives for improved drug treatment

Bing-Hua Jiang et al.

DRUG RESISTANCE UPDATES (2008)

Review Pharmacology & Pharmacy

Challenges in developing targeted therapy for pancreatic adenocarcinoma

Devalingam Mahalingam et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2008)

Article Biochemistry & Molecular Biology

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

Bruno D. Fonseca et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Oncology

Gene expression profiling in sarcomas

Katharina Tschoep et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2007)

Article Biochemistry & Molecular Biology

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Laura R. Pearce et al.

BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

The proline-rich akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

Noriko Oshiro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

Lifu Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

P. J. Roberts et al.

ONCOGENE (2007)

Article Biochemistry & Molecular Biology

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Yasemin Sancak et al.

MOLECULAR CELL (2007)

Article Cell Biology

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Emilie Vander Haar et al.

NATURE CELL BIOLOGY (2007)

Review Oncology

Disrupting insulin-like growth factor signaling as a potential cancer therapy

Deepali Sachdev et al.

MOLECULAR CANCER THERAPEUTICS (2007)

Article Biochemistry & Molecular Biology

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

Maria A. Frias et al.

CURRENT BIOLOGY (2006)

Article Oncology

The epidermal growth factor receptor pathway: A model for targeted therapy

Maurizio Scaltriti et al.

CLINICAL CANCER RESEARCH (2006)

Article Oncology

mTOR and cancer: insights into a complex relationship

David M. Sabatini

NATURE REVIEWS CANCER (2006)

Review Biochemistry & Molecular Biology

TOR signaling in growth and metabolism

S Wullschleger et al.

Review Biochemistry & Molecular Biology

TOR signaling in growth and metabolism

Stephan Wullschleger et al.

Article Biochemistry & Molecular Biology

Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin

G Ohji et al.

JOURNAL OF BIOCHEMISTRY (2006)

Review Biotechnology & Applied Microbiology

Exploiting the PI3K/AKT pathway for cancer drug discovery

BT Hennessy et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Review Medicine, Research & Experimental

Mammalian target of rapamycin as a therapeutic target in leukemia

FJ Giles et al.

CURRENT MOLECULAR MEDICINE (2005)

Article Biochemistry & Molecular Biology

Molecular organization of target of rapamycin complex 2

S Wullschleger et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

The coordinate regulation of the p53 and rnTOR pathways in cells

ZH Feng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

The serine/threonine kinase pim-1

M Bachmann et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)

Article Multidisciplinary Sciences

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

DD Sarbassov et al.

SCIENCE (2005)

Review Biochemistry & Molecular Biology

eIF4E - from translation to transformation

Y Mamane et al.

ONCOGENE (2004)

Article Multidisciplinary Sciences

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

HG Wendel et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

Raptor, a binding partner of target of rapamycin

K Yonezawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Cell Biology

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

XS Gao et al.

NATURE CELL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

K Hara et al.

Review Pathology

IGF-I receptor signalling in transformation and differentiation

B Valentinis et al.

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY (2001)

Review Biochemistry & Molecular Biology

TOR, a central controller of cell growth

T Schmelzle et al.

Review Oncology

Role of the insulin-like growth factor family in cancer development and progression

H Yu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)

Review Cell Biology

Understanding Ras: 'it ain't over 'til it's over'

JM Shields et al.

TRENDS IN CELL BIOLOGY (2000)