期刊
FUTURE MICROBIOLOGY
卷 13, 期 11, 页码 1215-1223出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2018-0077
关键词
antibiotic multidrug-resistant; endolysin; mouse model; Streptococcus pneumoniae; synergy; zebrafish model
类别
资金
- Ministerio de Economia y Competitividad (MINECO) [SAF2017-88664, SAF2017-83388]
- CIBER de Enfermedades Respiratorias (CIBERES), an initiative of the Instituto de Salud Carlos III (ISCIII)
Aim: To test the synergistic effect of Cpl-711 endolysin and antibiotics for antipneumococcal activity. Materials & methods: A combination of Cpl-711 and different antibiotics (amoxicillin, cefotaxime, levofloxacin and vancomycin) was tested in a checkerboard assay against several multidrug-resistant Streptococcus pneumoniae strains. Mouse and zebrafish models of pneumococcal sepsis were used to confirm the in vitro data. Results: The activity of Cpl-711 combined with amoxicillin or cefotaxime was synergistic in the bactericidal effect against a serotype 23F multiresistant clinical isolate of S. pneumoniae. Synergy between Cpl-711 and cefotaxime was validated using both mouse and zebrafish models. Conclusion: Combination of Cpl-711 and cefotaxime may help in the treatment of diseases caused by multiresistant pneumococcal strains. Graphical abstract [GRAPHICS] .
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