期刊
FUTURE MICROBIOLOGY
卷 9, 期 11, 页码 1283-1293出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.14.87
关键词
gene regulation; transition metal ion homoeostasis; two-component signal transduction systems
类别
资金
- Cell Signals Fellowship [CIHR-STP-53877]
- [NIH R01DE013230]
- [CIHR-MT15431]
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE013230] Funding Source: NIH RePORTER
Bacteria have evolved various strategies to contend with high concentrations of environmental heavy metal ions for rapid, adaptive responses to maintain cell viability. Evidence gathered in the past two decades suggests that bacterial two-component signal transduction systems (TCSTSs) are intimately involved in monitoring cation accumulation, and can regulate the expression of related metabolic and virulence genes to elicit adaptive responses to changes in the concentration of these ions. Using examples garnered from recent studies, we summarize the cross-regulatory relationships between metal ions and TCSTSs. We present evidence of how bacterial TCSTSs modulate metal ion homeostasis and also how metal ions, in turn, function to control the activities of these signaling systems linked with bacterial survival and virulence.
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