期刊
FUTURE MICROBIOLOGY
卷 8, 期 7, 页码 901-921出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb.13.57
关键词
acyl-homoserine lactone signals; biofilm; Pseudomonas aeruginosa; quorum sensing; quorum sensing inhibitors; resistance; signal molecules; tolerance
类别
资金
- Danish Strategical Research Council
- German CF organization
- Villum foundation
- Novoseeds
- Lundbeckfonden
Bacterial resistance to conventional antibiotics combined with an increasing acknowledgement of the role of biofilms in chronic infections has led to a growing interest in new antimicrobial strategies that target the biofilm mode of growth. In the aggregated biofilm mode, cell-to-cell communication systems involved in the process known as quorum sensing regulate coordinated expression of virulence with immune shielding mechanisms and antibiotic resistance. For two decades, the potential of interference with quorum sensing by small chemical compounds has been investigated with the aim of developing alternative antibacterial strategies. Here, we review state of the art research of quorum sensing inhibitors against the opportunistic human pathogen Pseudomonas aeruginosa, which is found in a number of biofilm-associated infections and identified as the predominant organism infecting the lungs of cystic fibrosis patients.
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