期刊
FUTURE MICROBIOLOGY
卷 8, 期 7, 页码 887-899出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb.13.53
关键词
adaptation; amplification; antibiotic resistance; copy number variation; duplication; experimental evolution; horizontal gene transfer; next-generation sequencing; pathogens; rearrangements
类别
资金
- National Science Foundation [MCB 0920893, DBI 0905829]
- School of Science at the College of New Jersey
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0920893] Funding Source: National Science Foundation
The rapid pace of genomic sequence analysis is increasing the awareness of intrinsically dynamic genetic landscapes. Gene duplication and amplification (GDA) contribute to adaptation and evolution by allowing DNA regions to expand and contract in an accordion-like fashion. This process affects diverse aspects of bacterial infection, including antibiotic resistance and host-pathogen interactions. In this review, microbial GDA is discussed, primarily using recent bacterial examples that demonstrate medical and evolutionary consequences. Interplay between GDA and horizontal gene transfer further impact evolutionary trajectories. Complementing the discovery of gene duplication in clinical and environmental settings, experimental evolution provides a powerful method to document genetic change over time. New methods for GDA detection highlight both its importance and its potential application for genetic engineering, synthetic biology and biotechnology.
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