期刊
FUTURE MICROBIOLOGY
卷 7, 期 8, 页码 991-1002出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.12.74
关键词
biofilm; gene; Klebsiella; nosocomial; pathogenesis; type 3 fimbriae
类别
资金
- NIH [RO1AI1050011]
The Gram-negative opportunistic pathogen Klebsiella pneumonic:le is responsible for causing a spectrum of nosocomial and community-acquired infections. Globally, K. pneumoniae is a frequently encountered hospital-acquired opportunistic pathogen that typically infects patients with indwelling medical devices. Biofilm formation on these devices is important in the pathogenesis of these bacteria, and in K. pneumoniae, type 3 fimbriae have been identified as appendages mediating the formation of biofilms on biotic and abiotic surfaces. The factors influencing the regulation of type 3 fimbrial gene expression are largely unknown but recent investigations have indicated that gene expression is regulated, at least in part, by the intracellular levels of cyclic di-GMP. In this review, we have highlighted the recent studies that have worked to elucidate the mechanism by which type 3 fimbrial expression is controlled and the studies that have established the importance of type 3 fimbriae for biofilm formation and nosocomial infection by K. pneumoniae.
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