相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Activities of TMC207, Rifampin, and Pyrazinamide against Mycobacterium tuberculosis Infection in Guinea Pigs
Shaobin Shang et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase
Jee-Hyun Kim et al.
NUCLEIC ACIDS RESEARCH (2011)
Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor
E. Huitric et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals Are Uniformly Susceptible to Benzothiazinones
Maria Rosalia Pasca et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients
Andreas H. Diacon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis
Claudia Sala et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates
Oluseye K. Onajole et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Pharmacokinetics and Whole-Blood Bactericidal Activity against Mycobacterium tuberculosis of Single Doses of PNU-100480 in Healthy Volunteers
Robert S. Wallis et al.
JOURNAL OF INFECTIOUS DISEASES (2010)
Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-D-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis
Claudia Trefzer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery
Manoj Kumar et al.
MOLECULAR DIVERSITY (2010)
The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin
Radhika Gupta et al.
NATURE MEDICINE (2010)
Development of a repressible mycobacterial promoter system based on two transcriptional repressors
Francesca Boldrin et al.
NUCLEIC ACIDS RESEARCH (2010)
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection
Joeli Marrero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Development of New Anti-tuberculosis Drug Candidates
Ruiru Shi et al.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Leads for antitubercular compounds from kinase inhibitor library screens
Sophie Magnet et al.
TUBERCULOSIS (2010)
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Kevin Pethe et al.
NATURE COMMUNICATIONS (2010)
New Antituberculous Drugs in Development
Umesh G. Lalloo et al.
Current HIV/AIDS Reports (2010)
Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase
Alvin W. Hung et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model
K. N. Williams et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
In Vitro Model of Mycobacterial Growth Arrest Using Nitric Oxide with Limited Air
Syed Hussain et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
The Diarylquinoline R207910 Is Bactericidal against Mycobacterium leprae in Mice at Low Dose and Administered Intermittently
Robert Gelber et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects
Ann M. Ginsberg et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA
Katherine A. Rawls et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Synthesis of novel [1,2]-diamines with antituberculosis activity
Qingyi Meng et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
CarD Is an Essential Regulator of rRNA Transcription Required for Mycobacterium tuberculosis Persistence
Christina L. Stallings et al.
CELL (2009)
Structural genomics approach to drug discovery for Mycobacterium tuberculosis
Thomas R. Loerger et al.
CURRENT OPINION IN MICROBIOLOGY (2009)
Pristinamycin-inducible gene regulation in mycobacteria
Francesca Forti et al.
JOURNAL OF BIOTECHNOLOGY (2009)
Structure-Based Design of DevR Inhibitor Active against Nonreplicating Mycobacterium tuberculosis
Rajesh Kumar Gupta et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Tuberculosis and diabetes mellitus: convergence of two epidemics
Kelly E. Dooley et al.
LANCET INFECTIOUS DISEASES (2009)
Inhibitors selective for mycobacterial versus human proteasomes
Gang Lin et al.
NATURE (2009)
Synthetic EthR inhibitors boost antituberculous activity of ethionamide
Nicolas Willand et al.
NATURE MEDICINE (2009)
The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis
Andreas H. Diacon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen
Chirajyoti Deb et al.
PLOS ONE (2009)
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov et al.
SCIENCE (2009)
Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
Jean-Emmanuel Hugonnet et al.
SCIENCE (2009)
Antituberculosis activity of the molecular libraries screening center network library
Joseph A. Maddry et al.
TUBERCULOSIS (2009)
New anti-tuberculosis agents amongst known drugs
Kathryn E. A. Lougheed et al.
TUBERCULOSIS (2009)
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv
Subramaniam Ananthan et al.
TUBERCULOSIS (2009)
High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors
Thierry Christophe et al.
PLOS PATHOGENS (2009)
Biology of trans-Translation
Kenneth C. Keiler
ANNUAL REVIEW OF MICROBIOLOGY (2008)
Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis
R. Rustomjee et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Case Series Report of a Linezolid-Containing Regimen for Extensively Drug-Resistant Tuberculosis*
Rany Condos et al.
CHEST (2008)
Signalling Inhibitors Against Mycobacterium tuberculosis - Early Days of a New Therapeutic Concept in Tuberculosis
B. Hegymegi-Barakonyi et al.
CURRENT MEDICINAL CHEMISTRY (2008)
A novel drug discovery concept for tuberculosis:: Inhibition of bacterial and host cell signalling
Rita Szekely et al.
IMMUNOLOGY LETTERS (2008)
The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation
Marie Lavollay et al.
JOURNAL OF BACTERIOLOGY (2008)
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
Anil Koul et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit
Joseph A. Ippolito et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
A synthetic mammalian gene circuit reveals antituberculosis compounds
Wilfried Weber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
Srinivasa P. S. Rao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
Ramandeep Singh et al.
SCIENCE (2008)
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice
Sheetal Gandotra et al.
NATURE MEDICINE (2007)
Fragment-based approaches to enzyme inhibition
Alessio Ciulli et al.
CURRENT OPINION IN BIOTECHNOLOGY (2007)
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides
Xin Hea et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence
Catherine R. Stevenson et al.
BMC PUBLIC HEALTH (2007)
Diabetes and the risk of tuberculosis: a neglected threat to public health?
Catherine R. Stevenson et al.
CHRONIC ILLNESS (2007)
Location of persisting mycobacteria in a guinea pig model of tuberculosis revealed by R207910
Anne J. Lenaerts et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB
Matthew B. Soellner et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors
Richard J. Payne et al.
CHEMMEDCHEM (2007)
Silencing essential protein secretion in Mycobacterium smegmatis by using tetracycline repressors
Xinzheng V. Guo et al.
JOURNAL OF BACTERIOLOGY (2007)
M-tuberculosis and M-leprae translocate from the phagolysosome to the cytosol in myeloid cells
Nicole van der Wel et al.
CELL (2007)
Diarylquinolines target subunit c of mycobacterial ATP synthase
Anil Koul et al.
NATURE CHEMICAL BIOLOGY (2007)
Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein
Ruben C. Hartkoorn et al.
TUBERCULOSIS (2007)
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis
Sang Hyun Cho et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Drug therapy of experimental tuberculosis (TB): Improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs
Boris V. Nikonenko et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles
Hirofumi Sasaki et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
Makoto Matsumoto et al.
PLOS MEDICINE (2006)
Mycobacterium leprae is naturally resistant to PA-824
Ujjini H. Manjunatha et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid
Catherine Vilcheze et al.
NATURE MEDICINE (2006)
Antibacterial drug discovery and structure-based design
John J. Barker
DRUG DISCOVERY TODAY (2006)
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis
TW Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
UH Manjunatha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis
Todd J. Sullivan et al.
ACS CHEMICAL BIOLOGY (2006)
Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug
J Jia et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines
M Protopopova et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)
Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
EJ Muñoz-Elías et al.
NATURE MEDICINE (2005)
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
K Andries et al.
SCIENCE (2005)
Tuberculosis - Metabolism and respiration in the absence of growth
HIM Boshoff et al.
NATURE REVIEWS MICROBIOLOGY (2005)
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor
S Ehrt et al.
NUCLEIC ACIDS RESEARCH (2005)
Tetracycline-inducible gene regulation in mycobacteria
MCJ Blokpoel et al.
NUCLEIC ACIDS RESEARCH (2005)
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism -: Novel insights into drug mechanisms of action
HIM Boshoff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structural bioinformatic approaches to the discovery of new antimycobacterial drugs
K Kantardjieff et al.
CURRENT PHARMACEUTICAL DESIGN (2004)
Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis
CE Barry et al.
CURRENT PHARMACEUTICAL DESIGN (2004)
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator
J Engohang-Ndong et al.
MOLECULAR MICROBIOLOGY (2004)
M-tuberculosis persistence, latency, and drug tolerance
JE Gomez et al.
TUBERCULOSIS (2004)
The immunological aspects of latency in tuberculosis
J Chan et al.
CLINICAL IMMUNOLOGY (2004)
Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter
C Changsen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
Genetic requirements for mycobacterial survival during infection
CM Sassetti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Gene regulation by tetracyclines - Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes
C Berens et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)
Targeting tuberculosis and malaria through inhibition of enoyl reductase
MR Kuo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Genes required for mycobacterial growth defined by high density mutagenesis
CM Sassetti et al.
MOLECULAR MICROBIOLOGY (2003)
Comparative mycobacterial genomics as a tool for drug target and antigen discovery
ST Cole
EUROPEAN RESPIRATORY JOURNAL (2002)
Tetrazolium microplate assay as a rapid and inexpensive colorimetric method for determination of antibiotic susceptibility of Mycobacterium tuberculosis
L Caviedes et al.
JOURNAL OF CLINICAL MICROBIOLOGY (2002)
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
JC Betts et al.
MOLECULAR MICROBIOLOGY (2002)
Massive gene decay in the leprosy bacillus
ST Cole et al.
NATURE (2001)
Nonreplicating persistence of Mycobacterium tuberculosis
LG Wayne et al.
ANNUAL REVIEW OF MICROBIOLOGY (2001)
Detection of mRNA transcripts and active transcription in persistent Mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide
YM Hu et al.
JOURNAL OF BACTERIOLOGY (2000)
A specificity-enhancing factor for the ClpXP degradation machine
I Levchenko et al.
SCIENCE (2000)
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
CK Stover et al.
NATURE (2000)
分享论文
