期刊
FUTURE MICROBIOLOGY
卷 5, 期 1, 页码 23-41出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.09.108
关键词
antivirals; cell signaling; influenza virus; interferon; NS1; pandemic; vaccines
类别
资金
- NIH [R01 AI46954, U19 AI62623, U54 AI57158]
- Center for Research on Influenza Pathogenesis (CRIP) [HHSN266200700010C]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI046954, U19AI062623, U54AI057158] Funding Source: NIH RePORTER
Influenza viruses are globally important human respiratory pathogens. These viruses cause seasonal epidemics and occasional worldwide pandemics, both of which can vary significantly in disease severity, The virulence of a particular influenza virus strain is partly determined by its success in circumventing the host immune response. This article briefly reviews the innate mechanisms that host cells have evolved to resist virus infection, and outlines the plethora of strategies that influenza viruses have developed in order to counteract such powerful defences. The molecular details of this virus-host interplay are summarized, and the ways in which research in this area is being applied to the rational design of protective vaccines and novel antivirols are discussed.
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