期刊
FUTURE MICROBIOLOGY
卷 4, 期 4, 页码 401-412出版社
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.09.10
关键词
bacteria; Campylobacter jejuni; glycoengineering; glycosylation; PglB; vaccine
类别
资金
- BBSRC
- Gates Foundation
- BBSRC [BB/F009321/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F009321/1] Funding Source: researchfish
Traditionally, glycoproteins have been considered the exclusive property of eukaryotes and archaea, but it is now evident that glycoproteins are found in all domains of life. In recent years Winked glycosylation among some epsilon-proteobacteria has emerged as a new and exciting research area and represents a useful model to understand this complex process in simple, genetically tractable bacteria. Above all, the transfer of Winked glycosylation systems to the work-horse bacterium, Escherichia coli, has enabled, for the first time, the production of recombinant glycoproteins. This has potentially provided the option for tailor-made glycoproteins and has opened up the field of glycoengineering, particularly with respect to the development of glycoconjugate vaccines.
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