期刊
FUTURE MICROBIOLOGY
卷 4, 期 2, 页码 223-240出版社
FUTURE MEDICINE LTD
DOI: 10.2217/17460913.4.2.223
关键词
genetic variability; Helicobacter pylori; pathogenicity; virulence factors
类别
资金
- Foundation for the Support of Research in the State of Sao Paulo (FAPESP)
- Brazilian National Council for Scientific and Technological Development (CNPq)
- National Coordinating Committee for the Training of University Personnel (CAPES)
Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes the gastric mucus overlying the epithelium of the stomach in more than 50% of the world's population, This gastric colonization induces chronic gastric inflammation in all infected individuals, but only induces clinical diseases in 10-20% of infected individuals. These include peptic ulcers, acute and atrophic gastritis, intestinal metaplasia, gastric adenocarcinoma and gastric B-cell lymphoma. Various bacterial virulence factors are associated with the development of such gastric diseases, and the characterization of these markers could aid medical prognosis, which could be extremely important in predicting clinical outcomes. The purpose of this review is to summarize the role of the phenotypes, virulence-related genes and genotypes of H. pylori in the establishment of gastric colonization and the development of associated diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据