相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Synthesis and Radiopharmacological Characterisation of a Fluorine-18-Labelled Azadipeptide Nitrile as a Potential PET Tracer for invivo Imaging of Cysteine Cathepsins
Reik Loeser et al.
CHEMMEDCHEM (2013)
New Uses for Old Drugs: Attempts to Convert Quinolone Antibacterials into Potential Anticancer Agents Containing Ruthenium
Jakob Kljun et al.
INORGANIC CHEMISTRY (2013)
Cystatin C Properties Crucial for Uptake and Inhibition of Intracellular Target Enzymes
Hanna Wallin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Development of New Cathepsin B Inhibitors: Combining Bioisosteric Replacements and Structure-Based Design To Explore the Structure-Activity Relationships of Nitroxoline Derivatives
Izidor Sosic et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
Melanie Bruchard et al.
NATURE MEDICINE (2013)
Microbial and fungal protease inhibitors-current and potential applications
Jerica Sabotic et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)
Fluorescent nitrile-based inhibitors of cysteine cathepsins
Maxim Frizler et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Cathepsin B cleavable novel prodrug Ac-Phe-Lys-PABC-ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis An experimental study
Li-Hua Shao et al.
CANCER (2012)
Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer
Nimali P. Withana et al.
CANCER RESEARCH (2012)
Protease signalling: the cutting edge
Boris Turk et al.
EMBO JOURNAL (2012)
Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells
Spela Magister et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2012)
Novel cathepsin B-sensitive paclitaxel conjugate: Higher water solubility, better efficacy and lower toxicity
Liang Liang et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Synthesis and Biological Characterization of Protease-Activated Prodrugs of Doxazolidine
Benjamin L. Barthel et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
Neil D. Rawlings et al.
NUCLEIC ACIDS RESEARCH (2012)
Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex
Rosana Hudej et al.
ORGANOMETALLICS (2012)
Differential impact of cysteine cathepsins on genetic mouse models of de novo carcinogenesis: cathepsin B as emerging therapeutic target
Thomas Reinheckel et al.
FRONTIERS IN PHARMACOLOGY (2012)
Inhibition of Cathepsin K for Treatment of Osteoporosis
Steven Boonen et al.
CURRENT OSTEOPOROSIS REPORTS (2012)
Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease
Israel Schechter et al.
BIOLOGICAL CHEMISTRY (2011)
New Cathepsin Inhibitors to Explore the Fluorophilic Properties of the S2 Pocket of Cathepsin B: Design, Synthesis, and Biological Evaluation
Santos Fustero et al.
CHEMISTRY-A EUROPEAN JOURNAL (2011)
Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds
Bojana Mirkovic et al.
CHEMMEDCHEM (2011)
Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3, 5-triazin-2(1H)-ones as inhibitors of cathepsin B
Izidor Sosic et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Internalization of Exogenous Cystatin F Supresses Cysteine Proteases and Induces the Accumulation of Single-chain Cathepsin L by Multiple Mechanisms
Jeff D. Colbert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structural Optimization of Azadipeptide Nitriles Strongly Increases Association Rates and Allows the Development of Selective Cathepsin Inhibitors
Maxim Frizler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Overexpression of Cathepsin Z Contributes to Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
Jian Wang et al.
PLOS ONE (2011)
Cystatins - Extra- and intracellular cysteine protease inhibitors: High-level secretion and uptake of cystatin C in human neuroblastoma cells
Hanna Wallin et al.
BIOCHIMIE (2010)
Development of Nitrile-Based Peptidic Inhibitors of Cysteine Cathepsins
Maxim Frizler et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2010)
Specialized roles for cysteine cathepsins in health and disease
Jochen Reiser et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer
Joong Sup Shim et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)
Friends and relations of the cystatin superfamily-new members and their evolution
W.M. Brown et al.
PROTEIN SCIENCE (2010)
Autocatalytic processing of procathepsin B is triggered by proenzyme activity
Jerica Rozman Pungercar et al.
FEBS JOURNAL (2009)
Regulation of cathepsin B activity by 2A2 monoclonal antibody
Bojana Mirkovic et al.
FEBS JOURNAL (2009)
Macrocypins, a family of cysteine protease inhibitors from the basidiomycete Macrolepiota procera
Jerica Sabotic et al.
FEBS JOURNAL (2009)
Inactivation of harmful tumour-associated proteolysis by nanoparticulate system
Janko Kos et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)
Dual contrasting roles of cysteine cathepsins in cancer progression: Apoptosis versus tumour invasion
Olga Vasiljeva et al.
BIOCHIMIE (2008)
Cysteine cathepsins: Cellular roadmap to different functions
Klaudia Brix et al.
BIOCHIMIE (2008)
Inhibitors of cathepsin B improve memory and reduce β-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, β-secretase site of the amyloid precursor protein
Vivian Y. H. Hook et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A double-headed cathepsin B inhibitor devoid of warhead
Patricia Schenker et al.
PROTEIN SCIENCE (2008)
Cysteine cathepsin proteases as pharmacological targets in cancer
Carmela Palermo et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes
Heiko Bueth et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2007)
Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions
Dejan Caglic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Influenza A virus elevates active cathepsin B in primary murine DC
Timo Burster et al.
INTERNATIONAL IMMUNOLOGY (2007)
Cysteine cathepsins: regulators of antitumour immune response
Natasa Obermajer et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2006)
Natural biflavones as novel inhibitors of cathepsin B and K
G. -Z. Zeng et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2006)
Cysteine cathepsins: multifunctional enzymes in cancer
Mona Mostafa Mohamed et al.
NATURE REVIEWS CANCER (2006)
Regulation of human cathepsin B by alternative mRNA splicing:: homeostasis, fatal errors and cell death
Antonio Baici et al.
BIOLOGICAL CHEMISTRY (2006)
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer
Olga Vasiljeva et al.
CANCER RESEARCH (2006)
Towards novel anti-cancer strategies based on cystatin function
Daniel Keppler
CANCER LETTERS (2006)
Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro
A Premzl et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
Inhibitors of cathepsin B
R. Frlan et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Targeting proteases: successes, failures and future prospects
Boris Turk
NATURE REVIEWS DRUG DISCOVERY (2006)
Lysosomal cysteine proteases: Structure, function and inhibition of cathepsins
R Roberts
DRUG NEWS & PERSPECTIVES (2005)
Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L
L Puzer et al.
BIOLOGICAL CHEMISTRY (2005)
Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B
WL Pan et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host
C Kopitz et al.
CANCER RESEARCH (2005)
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells:: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
V Hook et al.
BIOLOGICAL CHEMISTRY (2005)
Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
K Chandran et al.
SCIENCE (2005)
Cathepsin B in osteoarthritis:: Uncontrolled proteolysis in the wrong place
A Baici et al.
SEMINARS IN ARTHRITIS AND RHEUMATISM (2005)
Chiral cyclopalladated complexes derived from N,N-dimethyl-1-phenethylamine with bridging bis(diphenylphosphine)ferrocene ligand as inhibitors of the cathepsin B activity and as antitumoral agents
C Bincoletto et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Inhibitory properties of cystatin F and its localization in U937 promonocyte cells
T Langerholc et al.
FEBS JOURNAL (2005)
Proteinaceous cysteine protease inhibitors
G Dubin
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B
RLOR Cunha et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Cysteine proteases as disease markers
I Berdowska
CLINICA CHIMICA ACTA (2004)
Strategy in inhibition of cathepsin B, A target in tumor invasion and metastasis
IT Lim et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Multiple roles for cysteine cathepsins in cancer
JA Joyce et al.
CELL CYCLE (2004)
HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration
H Büth et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2004)
RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
CS Gondi et al.
ONCOGENE (2004)
Recombinant human cathepsin H lacking the mini chain is an endopeptidase
O Vasiljeva et al.
BIOCHEMISTRY (2003)
NF-κB protects from the lysosomal pathway of cell death
N Liu et al.
EMBO JOURNAL (2003)
Human and mouse proteases:: A comparative genomic approach
XS Puente et al.
NATURE REVIEWS GENETICS (2003)
Pericellular cathepsin B and malignant progression
S Roshy et al.
CANCER AND METASTASIS REVIEWS (2003)
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro
A Premzl et al.
EXPERIMENTAL CELL RESEARCH (2003)
Lysosomal cysteine proteases (cathepsins): promising drug targets
D Turk et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2003)
3-acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors
NE Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
1,2,4-thiadiazole: A novel Cathepsin B inhibitor
R Leung-Toung et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells
SD Konduri et al.
ONCOGENE (2002)
Molecular cloning and chimerisation of an inhibitory anti-cathepsin B antibody and its expression in Chinese hamster ovary cells
Xiaohui Fan et al.
BIOLOGICAL CHEMISTRY (2002)
Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity
GJD Van Acker et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Neuronal loss and brain atrophy in mice lacking cathepsins B and L
U Felbor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Lysosomal enzymes, cathepsins in brain tumour invasion
N Levicar et al.
JOURNAL OF NEURO-ONCOLOGY (2002)
S′2 substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B
JC Krupa et al.
BIOCHEMICAL JOURNAL (2002)
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design
PD Greenspan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Lysosomal cysteine proteases: facts and opportunities
V Turk et al.
EMBO JOURNAL (2001)
Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis
Y Hashimoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities
C Therrien et al.
BIOCHEMISTRY (2001)
Cathepsin B activity regulation - Heparin-like glycosaminoglycans protect human cathepsin B from alkaline pH-induced inactivation
PC Almeida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Cathepsin B contributes to TNF-α-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
ME Guicciardi et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Bioactive marine metabolites.: Part 104.: Miraziridine A, a novel cysteine protease inhibitor from the marine sponge Theonella aff. mirabilis
Y Nakao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Development of peptidyl α-keto-β-aldehydes as new inhibitors of cathepsin L -: Comparisons of potency and selectivity profiles with cathepsin B
JF Lynas et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
D Greenbaum et al.
CHEMISTRY & BIOLOGY (2000)
Lysosomal cysteine protease, cathepsin B, is targeted to lysosomes by the mannose 6-phosphate-independent pathway in rat hepatocytes: Site-specific phosphorylation in oligosaccharides of the proregion
Y Tanaka et al.
JOURNAL OF BIOCHEMISTRY (2000)
Clitocypin, a new type of cysteine proteinase inhibitor from fruit bodies of mushroom Clitocybe nebularis
J Brzin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain in ovalbumin-immunized mice
T Zhang et al.
IMMUNOLOGY (2000)
Probing the specificity of cysteine proteinases at subsites remote from the active site:: analysis of P4, P3, P2′ and P3′ variations in extended substrates
FCV Portaro et al.
BIOCHEMICAL JOURNAL (2000)
Unraveling the role of proteases in cancer
JE Koblinski et al.
CLINICA CHIMICA ACTA (2000)
Haim-Munk syndrome and Papillon-Lefevre syndrome are allelic mutations in cathepsin C
TC Hart et al.
JOURNAL OF MEDICAL GENETICS (2000)
Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase
I Klemencic et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
M Bogyo et al.
CHEMISTRY & BIOLOGY (2000)
分享论文
