期刊
FUTURE MEDICINAL CHEMISTRY
卷 6, 期 13, 页码 1499-1513出版社
FUTURE SCI LTD
DOI: 10.4155/FMC.14.100
关键词
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资金
- Portuguese Foundation for Science and Technology (FCT)
- COMPETE/FEDER [PTDC/SAU-TOX/117912/2010, PTDC/QUI-QUI/101409/2008, PEst-C/SAU/LA0001/2013-2014]
- FCT [SFRH/BPD/75959/2011]
There are many approaches used to control breast cancer, although the most efficient strategy is the reactivation of apoptosis. Since mitochondria play an important role in cellular metabolism and homeostasis, as well as in the regulation of cell death pathways, we focus here on metabolic remodeling and mitochondrial alterations present in breast tumor cells. We review strategies including classes of compounds and delivery systems that target metabolic and specific mitochondrial alterations to kill tumor cells without affecting their normal counterparts. We present here the arguments for the improvement of already existent molecules and the design of novel promising anticancer drug candidates that target breast cancer mitochondria.
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