相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Molecular Pathways: Regulation and Therapeutic Implications of Multidrug Resistance
Kevin G. Chen et al.
CLINICAL CANCER RESEARCH (2012)
Phase 1 study of the novel vascular disrupting agent plinabulin (NPI-2358) and docetaxel
Michael Millward et al.
INVESTIGATIONAL NEW DRUGS (2012)
A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer
Sunjoo Ahn et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)
The role of Tau protein in resistance to paclitaxel
Marta Smoter et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)
A phase I study of MN-029 (denibulin), a novel vascular-disrupting agent, in patients with advanced solid tumors
Alejandro D. Ricart et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)
Microwave-Assisted Synthesis of Medicinally Relevant Indoles
S. A. Patil et al.
CURRENT MEDICINAL CHEMISTRY (2011)
The P-glycoprotein multidrug transporter
Frances J. Sharom
ESSAYS IN BIOCHEMISTRY: ABC TRANSPORTERS (2011)
Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents
Mei-Jung Lai et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues
Martin Arthuis et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Phase I/II Study of Pemetrexed With or Without ABT-751 in Advanced or Metastatic Non-Small-Cell Lung Cancer
Charles M. Rudin et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors
Fuchun Xie et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability
Giuseppe La Regina et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: application of the copper-mediated Ullmann-type arylation
Hsueh-Yun Lee et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2011)
Rigid Analogues of Antimitotic Indolobenzazepinones: New Insights into Tubulin Binding via Molecular Modeling
Valerie Pons et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
A phase IB study of ABT-751 in combination with docetaxel in patients with advanced castration-resistant prostate cancer
J. Michels et al.
ANNALS OF ONCOLOGY (2010)
Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure-activity relationship of the quinazoline ring
Nilantha Sirisoma et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Pharmacokinetics of orally administered ABT-751 in children with neuroblastoma and other solid tumors
Elizabeth Fox et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)
Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas
Monica M. Mita et al.
CLINICAL CANCER RESEARCH (2010)
VERUBULIN HYDROCHLORIDE Apoptosis Inducer Vascular Disrupting Agent Oncolytic
P. Thomas et al.
DRUGS OF THE FUTURE (2010)
Structure-activity relationships of indole compounds derived from combretastatin A4: Synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents
Nancy Ty et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins
Concepcion Alvarez et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
A dose escalation, safety, and tolerability study of MN-029 in patients with advanced solid tumors
Anne M. Traynor et al.
INVESTIGATIONAL NEW DRUGS (2010)
I-387, a Novel Antimitotic Indole, Displays a Potent In vitro and In vivo Antitumor Activity with Less Neurotoxicity
Sunjoo Ahn et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Phase I Clinical Trial of MPC-6827 (Azixa), a Microtubule Destabilizing Agent, in Patients with Advanced Cancer
Apostolia-Maria Tsimberidou et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Microtubule-binding agents: a dynamic field of cancer therapeutics
Charles Dumontet et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Cancer Cells Acquire Mitotic Drug Resistance Properties Through Beta I-Tubulin Mutations and Alterations in the Expression of Beta-Tubulin Isotypes
Chun Hei Antonio Cheung et al.
PLOS ONE (2010)
Clinical Outcome in Children With Recurrent Neuroblastoma Treated With ABT-751 and Effect of ABT-751 on Proliferation of Neuroblastoma Cell Lines and on Tubulin Polymerization In Vitro
Holly J. Meany et al.
PEDIATRIC BLOOD & CANCER (2010)
Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents
Jang-Yang Chang et al.
MEDCHEMCOMM (2010)
Discovery of 4-Aryl-4H-Chromenes as Potent Apoptosis Inducers Using a Cell- and Caspase-Based Anti-Cancer Screening Apoptosis Program (ASAP): SAR Studies and the Identification of Novel Vascular Disrupting Agents
Sui Xiong Cai et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2009)
Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents
Pascal Marchand et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds
Raquel Alvarez et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Solid Phase Synthesis of Biologically Important Indoles
Shivaputra A. Patil et al.
CURRENT MEDICINAL CHEMISTRY (2009)
Solid-Phase Synthesis of Biologically Active Benzoannelated Nitrogen Heterocycles: An Update
Carmen Gil et al.
JOURNAL OF COMBINATORIAL CHEMISTRY (2009)
Indolobenzazepin-7-ones and 6-, 8-, and 9-Membered Ring Derivatives as Tubulin Polymerization Inhibitors: Synthesis and Structure-Activity Relationship Studies
Aurelien Putey et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies
Giuseppe La Regina et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration
Nilantha Sirisoma et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
From Nature to Drug Discovery: The Indole Scaffold as a 'Privileged Structure'
Fernando Rodrigues de Sa Alves et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)
Advances in Synthetic Approaches for the Preparation of Combretastatin-Based Anti-Cancer Agents
Rohit Singh et al.
SYNTHESIS-STUTTGART (2009)
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3′,4′,5′-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents
Nancy Ty et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents
Susanne Vogel et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization
Concepcion Alvarez et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Indole-3-carbinol as a chemopreventive and anti-cancer agent
Jing-Ru Weng et al.
CANCER LETTERS (2008)
A phase I study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 21 days every 28 days in pediatric patients with solid tumors
Elizabeth Fox et al.
CLINICAL CANCER RESEARCH (2008)
Synthetic applications of the Nenitzescu reaction to biologically active 5-hydroxyindoles
Shivaputra A. Patil et al.
CURRENT ORGANIC CHEMISTRY (2008)
Colchicine Site Inhibitors of Microtubule Integrity as Vascular Disrupting Agents
Ray M. Lee et al.
DRUG DEVELOPMENT RESEARCH (2008)
Synthesis and biological evaluation of 1-methyl-2-(3′,4′,5′-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors
Romeo Romagnoli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors
Jing-Ping Liou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: Cytotoxic and antitumor activities
Laurent Keller et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Human papillomavirus, cervical carcinogenesis and chemoprevention with Indole derivates - a review of pathomechanisms
Gudrun C. Rieck et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2008)
In vivo evaluation of indolyl glyoxamides in the phenotypic sea urchin embryo assay
Marina N. Semenova et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2007)
[(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G2/M phase and apoptosis
Michaela Pojarova et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Combretastatin A-4 phosphate -: Vascular disrupting agent, oncolytic, treatment of age-related macular degeneration
Daniel M. Patterson et al.
DRUGS OF THE FUTURE (2007)
4-and 5-aroylindoles as novel classes of potent antitubulin agents
Jing-Ping Liou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells
Doris Kaufmann et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure - activity relationships
Laixing Hu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Arylthioindole inhibitors of tubulin polymerization.: 3.: Biological evaluation, structure-activity relationships and molecular modeling studies
Giuseppe La Regina et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Synthesis and functionalization of indoles through rhodium-catalyzed reactions
Shivaputra Patil et al.
CURRENT ORGANIC SYNTHESIS (2007)
Indole, a core nucleus for potent inhibitors of tubulin polymerization
Andrea Brancale et al.
MEDICINAL RESEARCH REVIEWS (2007)
Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents
Laixing Hu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Vascular disrupting agents
John W. Lippert
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Small molecule vascular disrupting agents: Potential new drugs for cancer treatment
Sui X. Cai
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2007)
Recent uses of palladium chemistry in indole synthesis
Shivaputra Patil et al.
CURRENT ORGANIC SYNTHESIS (2006)
2-amino and 2′-aminocombretastatin derivatives as potent antimitotic agents
Jang-Yang Chang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Synthesis and biological evaluation of 2-(3′,4′,5′-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors
Romeo Romagnoli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Practical methodologies for the synthesis of indoles
Guy R. Humphrey et al.
CHEMICAL REVIEWS (2006)
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents
Gregory Dupeyre et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Synthesis and biological evaluation of 2-amino-3-(3′,4′,5′-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents
Romeo Romagnoli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
β-tubulin mutations in ovarian cancer using single strand conformation analysis-risk of false positive results from paraffin embedded tissues
H Gréen et al.
CANCER LETTERS (2006)
New arylthioindoles: Potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies
G De Martino et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Medicinal chemistry of combretastatin A4: Present and future directions
GC Tron et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent
B Nicholson et al.
ANTI-CANCER DRUGS (2006)
Synthesis and functionalization of Indoles through palladium-catalyzed reactions
S Cacchi et al.
CHEMICAL REVIEWS (2005)
Paclitaxel resistance in cells with reduced β-tubulin
YQ Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
EM Leslie et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
Bartoli indole synthesis
R Dalpozzo et al.
CURRENT ORGANIC CHEMISTRY (2005)
Statistical and generalized two-dimensional correlation spectroscopy of multiple ionization states. Fluorescence of neurotransmitter serotonin
GF Wang et al.
ANALYTICAL CHEMISTRY (2005)
Microtubules as a target for anticancer drugs
MA Jordan et al.
NATURE REVIEWS CANCER (2004)
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
RBG Ravelli et al.
NATURE (2004)
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents
JP Liou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections
JG Hurdle et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2004)
Arylthioindoles, potent inhibitors of tubulin polymerization
G De Martino et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo
CC Kuo et al.
CANCER RESEARCH (2004)
Synthetic approaches towards indoles on solid phase recent advances and future directions
J Tois et al.
TETRAHEDRON (2003)
Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents
WT Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
DA Horton et al.
CHEMICAL REVIEWS (2003)
The recent impact of solid-phase synthesis on medicinally relevant benzoannelated nitrogen heterocycles
S Bräse et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization
BL Flynn et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents
JP Liou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents
S Mahboobi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
New small-molecule tubulin inhibitors
G Bacher et al.
PURE AND APPLIED CHEMISTRY (2001)
Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents
SL Gwaltney et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
The solid-phase Nenitzescu indole synthesis
DM Ketcha et al.
TETRAHEDRON LETTERS (2000)
Recent developments in indole ring synthesis-methodology and applications
GW Gribble
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (2000)
分享论文
