相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Drug-like Properties: Guiding Principles for the Design of Natural Product Libraries
David Camp et al.
JOURNAL OF NATURAL PRODUCTS (2012)
Natural Products and Traditional Medicine: Turning on a Paradigm
Geoffrey A. Cordell et al.
JOURNAL OF NATURAL PRODUCTS (2012)
Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2012)
Syntheses of pseudoceramines A-D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges
J. Mikael Hillgren et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2012)
Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa
Rohan A. Davis et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Yin and Yang in medicinal chemistry: what does drug-likeness mean?
Ricardo Macarron et al.
FUTURE MEDICINAL CHEMISTRY (2011)
Natural Product Libraries to Accelerate the High-Throughput Discovery of Therapeutic Leads
Tyler A. Johnson et al.
JOURNAL OF NATURAL PRODUCTS (2011)
Impact of high-throughput screening in biomedical research
Ricardo Macarron et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Pseudoceramines A-D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.
Sheng Yin et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2011)
Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
MEDCHEMCOMM (2011)
Apparent activity in high-throughput screening: origins of compound-dependent assay interference
Natasha Thorne et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
Observations on screening-based research and some concerning trends in the literature
Jonathan B. Baell
FUTURE MEDICINAL CHEMISTRY (2010)
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
Jonathan B. Baell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Antitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine Sponge Plakortis sp.
Yunjiang Feng et al.
JOURNAL OF NATURAL PRODUCTS (2010)
Antimalarial Bromotyrosine Derivatives from the Australian Marine Sponge Hyattella sp.
Xinzhou Yang et al.
JOURNAL OF NATURAL PRODUCTS (2010)
Automated High-Throughput System to Fractionate Plant Natural Products for Drug Discovery
Ying Tu et al.
JOURNAL OF NATURAL PRODUCTS (2010)
Beyond discovery: probes that see, grab and poke
Joshua A. Kritzer
NATURE CHEMICAL BIOLOGY (2010)
Coexistence of passive and carrier-mediated processes in drug transport
Kiyohiko Sugano et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Merging structural biology with chemical biology: Structural Chemistry at Eskitis
Andreas Hofmann et al.
STRUCTURAL CHEMISTRY (2010)
Pseudoceratinazole A: a novel bromotyrosine alkaloid from the Australian sponge Pseudoceratina sp.
Yunjiang Feng et al.
TETRAHEDRON LETTERS (2010)
Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum
Yunjiang Feng et al.
TETRAHEDRON LETTERS (2010)
(+)-7-Bromotrypargine: an antimalarial β-carboline from the Australian marine sponge Ancorina sp.
Rohan A. Davis et al.
TETRAHEDRON LETTERS (2010)
(-)-Dibromophakellin: An α2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata
Rohan A. Davis et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
A Selective Account of Effective Paradigms and Significant Outcomes in the Discovery of Inspirational Marine Natural Products
Koneni V. Sashidhara et al.
JOURNAL OF NATURAL PRODUCTS (2009)
Antimalarial Activity of Azafluorenone Alkaloids from the Australian Tree Mitrephora diversifolia
Daniela Mueller et al.
JOURNAL OF NATURAL PRODUCTS (2009)
Antimalarial Benzylisoquinoline Alkaloid from the Rainforest Tree Doryphora sassafras
Malcolm S. Buchanan et al.
JOURNAL OF NATURAL PRODUCTS (2009)
Lessons from 60 years of pharmaceutical innovation
Bernard Munos
NATURE REVIEWS DRUG DISCOVERY (2009)
COMDECOM: Predicting the Lifetime of Screening Compounds in DMSO Solution
Emrin Zitha-Bovens et al.
JOURNAL OF BIOMOLECULAR SCREENING (2009)
Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
Gilbert M. Rishton
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
The impact of natural products upon modern drug discovery
A. Ganesan
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Natural products in drug discovery
Alan L. Harvey
DRUG DISCOVERY TODAY (2008)
Marine natural product libraries for high-throughput screening and rapid drug discovery
Tim S. Bugni et al.
JOURNAL OF NATURAL PRODUCTS (2008)
Developing a drug-like natural product library
Ronald J. Quinn et al.
JOURNAL OF NATURAL PRODUCTS (2008)
Pre-fractionated microbial samples - The second generation natural products library at Wyeth
Melissa M. Wagenaar
MOLECULES (2008)
A Tropical Marine Microbial Natural Products Geobibliography as an Example of Desktop Exploration of Current Research Using Web Visualisation Tools
Joydeep Mukherjee et al.
MARINE DRUGS (2008)
Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products
Jonathan Kennedy
NATURAL PRODUCT REPORTS (2008)
Natural products as a screening resource
Alan L. Harvey
CURRENT OPINION IN CHEMICAL BIOLOGY (2007)
The rule of five revisited: Applying log D in place of log p in drug-likeness filters
Sanjivanjit K. Bhal et al.
MOLECULAR PHARMACEUTICS (2007)
The Cost of Biopharmaceutical R&D: Is Biotech Different?
Joseph A. DiMasi et al.
MANAGERIAL AND DECISION ECONOMICS (2007)
Endiandrin a, a potent glucocorticoid receptor binder isolated from the australian plant Endiandra anthropophagorum
Rohan A. Davis et al.
JOURNAL OF NATURAL PRODUCTS (2007)
A simple method for high-throughput extract prefractionation for biological screening
David R. Appleton et al.
CHIMIA (2007)
Origin and evolution of high throughput screening
D. A. Pereira et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Screening in a spirit haunted world
Brian K. Shoichet
DRUG DISCOVERY TODAY (2006)
Chemical and biological integrity in natural products screening
GG Harrigan et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2005)
The evolving role of natural products in drug discovery
FE Koehn et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Time-related differences in the physical property profiles of oral drugs
PD Leeson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Pursuing the leadlikeness concept in pharmaceutical research
MM Hann et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 1: Synthetic strategy and preparation of a common precursor
SJ Mickel et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2004)
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 2: Synthesis of fragments C1-6 and C9-14
SJ Mickel et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2004)
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 3: Synthesis of fragment C15-21
SJ Mickel et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2004)
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 4: Preparation of fragment C7-24
SJ Mickel et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2004)
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 5: Linkage of fragments C1-6 and C7-24 and finale
SJ Mickel et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2004)
The effect of freeze/thaw cycles on the stability of compounds in DMSO
BA Kozikowski et al.
JOURNAL OF BIOMOLECULAR SCREENING (2003)
The price of innovation: new estimates of drug development costs
JA DiMasi et al.
JOURNAL OF HEALTH ECONOMICS (2003)
High-throughput method for the production and analysis of large natural product libraries for drug discovery
GR Eldridge et al.
ANALYTICAL CHEMISTRY (2002)
Modern methods to produce natural-product libraries
U Abel et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2002)
Characterization of binary solvent mixtures of DMSO with water and other cosolvents
J Catalán et al.
JOURNAL OF ORGANIC CHEMISTRY (2001)
Pure compound libraries; a new perspective for natural product based drug discovery
KU Bindseil et al.
DRUG DISCOVERY TODAY (2001)
Property-based design: Optimization of drug absorption and pharmacokinetics
H van de Waterbeemd et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B
C Cuevas et al.
ORGANIC LETTERS (2000)
ElogPoct:: A tool for lipophilicity determination in drug discovery
F Lombardo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Strategies for discovering drugs from previously unexplored natural products
A Harvey
DRUG DISCOVERY TODAY (2000)
分享论文
