期刊
FUTURE MEDICINAL CHEMISTRY
卷 4, 期 3, 页码 277-287出版社
FUTURE SCI LTD
DOI: 10.4155/fmc.11.176
关键词
Age-related macular degeneration; Geographic atrophy; Choroidal neovascularization; miRNA
资金
- Department of Ophthalmology at UT Southwestern Medical Center
- President's Research Council
- NIH [EY021862, EY020799]
- Research to Prevent Blindness
Since their recent discovery, miRNAs have been shown to play critical roles in a variety of pathophysiological processes. Such processes include pathological angiogenesis, the oxidative stress response, immune response and inflammation, all of which have been shown to have important and interdependent roles in the pathogenesis and progression of age-related macular degeneration (AMD). Here we present a brief review of the pathological processes involved in AMD and review miRNAs and other noncoding RNAs involved in regulating these processes. Specifically, we discuss several candidate miRNAs that show promise as AMD therapeutic targets due to their direct involvement in choroidal neovascularization or retinal pigment epithelium atrophy. We discuss potential miRNA-based therapeutics and delivery methods for AMD and provide future directions for the field of miRNA research with respect to AMD. We believe the future of miRNAs in AMD therapy is promising.
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