相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis
Barbara Renga et al.
PLOS ONE (2012)
Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter
Barbara Renga et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2011)
Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
Janne Prawitt et al.
DIABETES (2011)
Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure
Mitsuhiro Watanabe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Theonellasterols and Conicasterols from Theonella swinhoei. Novel Marine Natural Ligands for Human Nuclear Receptors
Simona De Marino et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Discovery of Sulfated Sterols from Marine Invertebrates as a New Class of Marine Natural Antagonists of Farnesoid-X-Receptor
Valentina Sepe et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
Sabrina Cipriani et al.
PLOS ONE (2011)
The bile acid sensor FXR regulates insulin transcription and secretion
Barbara Renga et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)
Targeting Farnesoid-X-Receptor: From Medicinal Chemistry to Disease Treatment
S. Fiorucci et al.
CURRENT MEDICINAL CHEMISTRY (2010)
The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity
Iuliana Ristea Popescu et al.
FEBS LETTERS (2010)
FARNESOID-X RECEPTOR AGONISTS: A NEW CLASS OF FOR THE TREATMENT OF PBC? AN INTERNATIONAL STUDY EVALUATING THE ADDITION OF INT-747 TO URSODEOXYCHOLIC ACID
A. Mason et al.
JOURNAL OF HEPATOLOGY (2010)
Bile acid-activated receptors in the treatment of dyslipidemia and related disorders
Stefano Fiorucci et al.
PROGRESS IN LIPID RESEARCH (2010)
Antiatherosclerotic effect of farnesoid X receptor
Andrea Mencarelli et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice
Helen B. Hartman et al.
JOURNAL OF LIPID RESEARCH (2009)
Bile acids: regulation of synthesis
John Y. L. Chiang
JOURNAL OF LIPID RESEARCH (2009)
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064
Adwoa Akwabi-Ameyaw et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The novel compounds that activate farnesoid X receptor: The diversity of their effects on gene expression
Takuo Suzuki et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2008)
Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation
Stephen M. Soisson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The farnesoid X receptor FXRα/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution
Shi-Ying Cai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
Targeting farnesoid X receptor for liver and metabolic disorders
Stefano Fiorucci et al.
TRENDS IN MOLECULAR MEDICINE (2007)
Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
Andreas Geier et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
Renata Belfort et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo
Giovanni Rizzo et al.
MOLECULAR PHARMACOLOGY (2006)
The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone
Shuguang Wang et al.
ENDOCRINOLOGY (2006)
Metabolic regulation by the nuclear receptor corepressor RIP140
Mark Christian et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)
Benefit of farnesoid X receptor inhibition in obstructive cholestasis
Catherine Stedman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis
A Mennone et al.
HEPATOLOGY (2006)
Nonalcoholic fatty liver disease: From steatosis to cirrhosis
GC Farrell et al.
HEPATOLOGY (2006)
Farnesoid X receptor: From structure to potential clinical applications
R Pellicciari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand
TP Burris et al.
MOLECULAR PHARMACOLOGY (2005)
The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis
C Corpechot et al.
GASTROENTEROLOGY (2005)
T0901317 is a dual LXR/FXR agonist
KA Houck et al.
MOLECULAR GENETICS AND METABOLISM (2004)
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid
R Pellicciari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Farnesoid X receptor represses hepatic lipase gene expression
A Sirvent et al.
JOURNAL OF LIPID RESEARCH (2004)
The farnesoid X receptor induces very low density lipoprotein receptor gene expression
A Sirvent et al.
FEBS LETTERS (2004)
Identification of gene-selective modulators of the bile acid receptor FXR
I Dussault et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
CJ Sinal et al.
CELL (2000)
分享论文
