A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans

The genome of Aspergillus nidulans carries 27 genes encoding nonribosomal peptide synthetase (NRPS) structures, although only five of these forming peptides and amino acid containing metabolites have been identified so far. This manuscript describes domain structures, Substrate binding pockets and related genes and gene clusters and summarizes our current state of product prediction of fungal NRPS systems. (C) 2008 Elsevier Inc. All rights reserved.