期刊
FUNDAMENTAL & CLINICAL PHARMACOLOGY
卷 27, 期 5, 页码 471-482出版社
WILEY
DOI: 10.1111/j.1472-8206.2012.01058.x
关键词
antidepressant-like effect; bis-eugenol; forced swimming test; high-performance liquid chromatography; monoaminergic system
资金
- CNPq
- CAPES
Dehydrodieugenol, known as bis-eugenol, is a eugenol ortho dimer, and both compounds were able to exhibit anti-inflammatory and antioxidant activities in previous studies. Furthermore, eugenol showed antidepressant-like effect; however, the biological actions of bis-eugenol on experimental models for screening antidepressant activity are still unknown. The present study investigated a possible antidepressant-like activity of bis-eugenol in the forced swimming test (FST) and tail suspension test (TST) in mice and the involvement in the monoaminergic system in this effect. In addition, a neurochemical analysis on brain monoamines of mice acutely treated with bis-eugenol was also conducted. Bis-eugenol decreased the immobility time in the FST and TST without accompanying changes in ambulation in the open field test at 10mg/kg, i.p.. Nevertheless, it induced ambulation at 25 and 50mg/kg doses. The anti-immobility effect of bis-eugenol (10 and 50mg/kg, i.p.) was prevented by pretreatment of mice with p-chlorophenylalanine (PCPA, 100mg/kg, i.p., an inhibitor of serotonin synthesis, for four consecutive days), yohimbine (1mg/kg, i.p., an 2-adrenoceptor antagonist), SCH23390 (15g/kg, s.c., a dopamine D1 receptor antagonist) and sulpiride (50mg/kg, i.p., a dopamine D2 receptor antagonist). Monoamines analysis using high-performance liquid chromatograph revealed significant increase in the 5-HT, NE and DA levels in brain striatum. The present study indicates that bis-eugenol possesses antidepressant-like activity in FST and TST by altering dopaminergic, serotonergic and noradrenergic systems function.
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