期刊
FUNDAMENTAL & CLINICAL PHARMACOLOGY
卷 26, 期 2, 页码 190-193出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1472-8206.2011.00928.x
关键词
cGMP; colitis; KATP; sildenafil
The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP-sensitive potassium channels (KATP) and cGMP, respectively.
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