期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 34, 期 2, 页码 88-94出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2012.11.001
关键词
GnRH receptor; G proteins; Pituitary gonadotropes; Sex hormone-dependent cancer cells
资金
- U.S.-Israel Binational Science Foundation [2007057]
- Israel Science Foundation [2011-2015]
- Adams Super-Center for Brain Studies at Tel-Aviv University
- Directorate For Geosciences
- Division Of Earth Sciences [2007057] Funding Source: National Science Foundation
G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner. (C) 2012 Elsevier Inc. All rights reserved.
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