期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 32, 期 4, 页码 426-450出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2011.07.001
关键词
Empathy; Oxytocin; Reinforcement learning; Psychiatric disorders; Social; Treatment
资金
- German Research Foundation (DFG) [HU1302/2-2]
- Ministry of Innovation, Science, Research and Technology of the German State of North Rhine-Westphalia (MIWFT)
- University of Bonn
There has been unprecedented interest in the prosocial effects of the neuropeptide oxytocin in humans over the last decade. A range of studies has demonstrated correlations between basal oxytocin levels and the strength of social and bonding behaviors both in healthy individuals and in those suffering from psychiatric disorders. Mounting evidence suggests associations between polymorphisms in the oxytocin receptor gene and prosocial behaviors and there may also be important epigenetic effects. Many studies have now reported a plethora of prosocial effects of intranasal application of oxytocin, including the domains of trust, generosity, socially reinforced learning, and emotional empathy. The main focus of this review will be to summarize human preclinical work and particularly the rapidly growing number of clinical studies which have identified important links between oxytocin and a wide range of psychiatric disorders, and have now started to directly assess its therapeutic potential. (C) 2011 Elsevier Inc. All rights reserved.
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