期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 31, 期 2, 页码 193-202出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2010.02.001
关键词
Neonate; Inflammation; Pain; Nociception; Development; Infant
资金
- National Institute of Health [DA16272, AR49555]
- Center for Behavioral Neuroscience NSF [IBN 9876754]
- Georgia State University
Over the last several decades, the relative contribution of early life events to individual disease susceptibility has been explored extensively. Only fairly recently, however, has it become evident that abnormal or excessive nociceptive activity experienced during the perinatal period may permanently alter the normal development of the CNS and influence future responses to somatosensory input. Given the significant rise in the number of premature infants receiving high-technology intensive care over the last 20 years, ex-preterm neonates may be exceedingly vulnerable to the long-term effects of repeated invasive interventions. The present review summarizes available clinical and laboratory findings on the lasting impact of exposure to noxious stimulation during early development, with a focus on the structural and functional alterations in nociceptive circuits, and its sexually dimorphic impact. (C) 2010 Elsevier Inc. All rights reserved.
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