期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 31, 期 1, 页码 104-112出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2009.10.004
关键词
Leptin; Dopamine; Midbrain; Ventral tegmental area; Nucleus accumbens; Prefrontal cortex; Obesity; Striatum
资金
- NIH [DK073677, DK076964]
- State of Connecticut, Department of Mental Health and Addiction Services
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK076964, R01DK073677] Funding Source: NIH RePORTER
Recent evidence has emerged demonstrating that metabolic hormones such as ghrelin and leptin can act on ventral tegmental area (VTA) midbrain dopamine neurons to influence feeding. The VIA is the origin of mesolimbic dopamine neurons that project to the nucleus accumbens (NAc) to influence behavior. While blockade of dopamine via systemic antagonists or targeted gene delete can impair food intake, local NAc dopamine manipulations have little effect on food intake. Notably, non-dopaminergic manipulations in the VTA and NAc produce more consistent effects on feeding and food choice. More recent genetic evidence supports a role for the substantia nigra-striatal dopamine pathways in food intake, while the VTA-NAc circuit is more likely involved in higher-order aspects of food acquisition, such as motivation and cue associations. This rich and complex literature should be considered in models of how peripheral hormones influence feeding behavior via action on the midbrain circuits. (C) 2009 Elsevier Inc. All rights reserved.
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