期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 31, 期 1, 页码 16-31出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2009.10.001
关键词
Hypothalamus; Development; Nutrition; Pregnancy; Food intake; Energy homeostasis; Obesity; Melanocortins; Neuropeptide Y; Arcuate nucleus
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD014643] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK079194, R01DK060685] Funding Source: NIH RePORTER
- NICHD NIH HHS [R01 HD014643] Funding Source: Medline
- NIDDK NIH HHS [R01 DK060685-03, R01 DK079194, R01 DK060685-04S1, R01 DK079194-01, R01 DK060685-04, R01 DK060685-01A2S1, R01 DK060685-02, R01 DK079194-02S1, R01 DK060685-02S1, R01 DK079194-03, R01 DK079194-02S2, R01 DK079194-02, R01 DK060685, R01 DK060685-05, R01 DK060685-03S1, R01 DK060685-01A2] Funding Source: Medline
Over the last decade there has been a striking increase in the early onset of metabolic disease, including obesity and diabetes. The regulation of energy homeostasis is complex and involves the intricate integration of peripheral and central systems, including the hypothalamus. This review provides an overview of the development of brain circuitry involved in the regulation of energy homeostasis as well as recent findings related to the impact of both prenatal and postnatal maternal environment on the development of these circuits. There is surprising evidence that both overnutrition and undernutrition impact the development of these circuits in a similar manner as well as having similar consequences of increased obesity and diabetes later in life. There is also a special focus on relevant species differences in the development of hypothalamic circuits. A deeper understanding of the mechanisms involved in the development of brain circuitry is needed to fully understand how the nutritional and/or maternal environments impact the functional circuitry as well as the behavior and physiological outcomes. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据