期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 30, 期 2, 页码 201-211出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2009.04.007
关键词
17 beta-Estradiol; Estrogen receptor; Estrogen therapy; Ischemia; Middle cerebral artery occlusion; Inflammation; Neurogenesis; Stroke; Women's health initiative
资金
- National Institutes of Health [AG17164, 02224]
- American Heart Association Post-doctoral Fellowship [0920086G]
- Ruth L. Kirschstein NRSA Postdoctoral Fellowship [AG 27614]
Our laboratory has investigated whether and how 17 beta-estradiol (E-2) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E-2, which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E-2. Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations. Published by Elsevier Inc.
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