期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 29, 期 3, 页码 386-397出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2008.03.003
关键词
maternal; epigenetic; DNA methylation; estrogen receptor alpha; oxytocin; environment; cross-fostering
资金
- NIH HHS [DP2 OD001674-01] Funding Source: Medline
The transmission of traits across generations has typically been attributed to the inheritance by offspring of genomic information from parental generations. However, recent evidence suggests that epigenetic mechanisms are capable of mediating this type of transmission. In the case of maternal care, there is evidence for the behavioral transmission of postpartum behavior from mothers to female offspring. The neuroendocrine and molecular mediators of this transmission have been explored in rats and implicate estrogen-oxytocin interactions and the differential methylation of hypothalamic estrogen receptors. These maternal effects can influence multiple aspects of neurobiology and behavior of offspring and this particular mode of inheritance is dynamic in response to environmental variation. In this review, evidence for the generational transmission of maternal care and the mechanisms underlying this transmission will be discussed as will the implications of this inheritance system for offspring development and for the transmission of environmental information from parents to offspring. (c) 2008 Elsevier Inc. All rights reserved.
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