期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 18, 期 -, 页码 1-U414出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4084
关键词
Alternative-Lengthening Of Telomeres; ALT; APB; Shelterin; Chromatin; DNA Methylation; Histone; Modifications; Review
资金
- Institut Curie (PIC replication)
- Ligue contre le cancer
Telomeres are nucleoprotein structures at the ends of linear chromosomes that protect them from being recognized as DNA double stranded breaks. Telomeres shorten with every cell division and in the absence of the checkpoint mechanisms critical telomere shortening leads to chromosome end fusions and genomic instability. Cancer cells achieve immortality by engaging in one of the two known mechanisms for telomere maintenance: elongation by telomerase or through recombination. Recombination based elongation of telomeres, also known as alternative lengthening of telomeres or ALT, is prevalent among cancers of mesenchymal origin. However, the conditions favoring ALT emergence are not known. Here we will discuss possible players in ALT mechanisms, including recruitment of telomeres to recombination centers, alterations of telomere associated proteins and modifications at the level of chromatin that could generate recombination permissive conditions at telomeres.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据