期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 18, 期 -, 页码 782-787出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4141
关键词
Graves' disease; IFN-gamma; IL-2; Review
资金
- Shanghai Municipal Science and Technology commission [10DZ1975000, 11DZ1972704]
- Natural Science Foundation of China [81072793]
Graves' disease (GD) is a systemic autoimmune syndrome manifesting complications in thyroid and orbital connective tissues. The thyroid gland plays a major role in the human body by producing the hormones necessary for appropriate energy levels and an active life. At the same time, the thyroid is highly vulnerable to autoimmune thyroid diseases. GD arises due to the complex interplay of genetic, environmental and endogenous factors, and the specific combination is required to initiate thyroid autoimmunity. Earlier studies have demonstrated the autoimmune response plays a dominant role in the development of GD. This review summarizes the inflammatory events which occur during the development of GD, such as Th17/Treg cell infiltration, Th1/Th2 cytokine and chemokine production, and the subtypes of immunogloblins (IgGs) generated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据