期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 18, 期 -, 页码 788-794出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4142
关键词
miRNAs; siRNAs; mRNA; Review
Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs (miRNAs) are non-coding small RNAs, usually 18-25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of miRNA in the osteosarcome.
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