期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 18, 期 -, 页码 356-365出版社
IMR PRESS
DOI: 10.2741/4106
关键词
Heat shock proteins; HSP70; Functional amino acids; Glutamine; Arginine, Review
资金
- National Basic Research Program of China [2012CB124704, 2009CB118806]
- NSFC [31101730, 31110103909, 31172217, 30901040, 30901041, 30928018]
- Chinese Academy of Sciences and Knowledge Innovation Project [KZCX2-EW-412]
- National Fund of Agricultural Science and Technology [2006GB24910468]
- Open Project Program of State Key Laboratory of Food Science and Technology, Nanchang University [SKLF-KF-201005, SKLF-TS-201108]
- China Postdoctoral Science Foundation [20110491493]
- Thousand-People Talent program at China Agricultural University
- Chinese Universities Scientific Fund [2012RC024]
- Texas AgriLife Research Hatch Project [H-8200]
Heat shock proteins (HSPs) are remarkably conserved in all living organisms. The upregulation of expression of HSPs is triggered by a variety of physiological and environmental insults. HSPs play an important role in protecting against protein denaturation and subsequent celluar stress, which damages the intestinal mucosa and reduces the protective function of the mucosal barrier, resulting in the formation of stress ulcers. Heat shock protein 70 (HSP70) is the most widely studied of all HSPs and has numerous important chaperoning functions. Stress accelerates the synthesis of HSP70, which in turn inhibits the apoptosis of intestinal mucosal cells. In this article, we review the main classification of HSPs, the expression and regulation of HSPs and their roles in stress ulcers. We also discuss the role of functional amino acids in regulating the expression of HSPs (particularly HSP70) and protecting the intestinal mucosa and other tissues.
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