期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 17, 期 -, 页码 54-64出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3915
关键词
Musashi1; RNA-Binding Protein; Cancer; Stem Cell; Cancer Stem Cell; Neurological Disease; Translational Regulation; Splicing; Ribonomics; Post-Transcriptional Gene Regulation; Nervous System Development; Review
资金
- National Cancer Institute [R01CA11482]
- National Institutes of Health
- The Charlotte Geyer Foundation
- Fighting Against Lung Cancer
- Cancer Therapy and Research Center
- American Cancer Society
- San Antonio Area Foundation
- Children's Brain Tumor Foundation
- TENGG-Bank of America Foundation
- Association for Research of Childhood Cancer
Musashi1 (Msi1) is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability to regulate sensory organ development and asymmetric cell division. Studies in mammalian cells reveal multiple functions for Musashi1 in normal and abnormal processes by mediating different post-transcriptional processes. According to our recent studies, Musashi1 very likely controls hundreds of targets, forming networks that regulate apoptosis, differentiation, proliferation and cell cycle. Musashi1 is a characteristic stem cell marker that regulates the balance between self-renewal and differentiation. Over-expression of Musashi1 has been associated with numerous tumor types and its function is required for tumor growth in breast, colon, medulloblastoma and glioblastoma. Musashi1 has also been implicated in neurogenesis and neurodegenerative diseases, and is emerging as a potential therapeutic target in both regenerative medicine and cancer.
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