期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 17, 期 -, 页码 90-99出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3917
关键词
Hedgehog signaling; Epidermal growth factor receptor; GLI transcription factors; JUN/AP-1 transcription factors; MEK/ERK Signaling; Oncogenic Transformation; Cancer; Combination Therapy; Review
资金
- Austrian Science Fund FWF [W1213, P20652]
- Austrian Genome Program GENAU/MedSys
- European Union [FP7]
- Health of the University of Salzburg
- Austrian Science Fund (FWF) [W1213, P20652] Funding Source: Austrian Science Fund (FWF)
It has been known for many years that cooperative interactions between oncogenes (e.g. RAS, MYC, BCL2) can fuel cancer growth (1-5), but the restricted druggability of many of those interacting cancer genes has hampered translation of combined targeting to medical cancer therapy. The identification and characterization of cooperative cancer signaling pathways amenable to medical therapy is therefore a crucial step towards the establishment of efficient targeted combination treatments urgently needed to improve cancer therapy. Here we review recent findings of our group and colleagues on the molecular mechanisms of cooperative Hedgehog/GLI and Epidermal Growth Factor Receptor (EGFR) signaling, two clinically relevant oncogenic pathways involved in the development of many human malignancies. We also discuss the possible implications of these findings for the design of a therapeutic regimen relying on combined targeting of key effectors of both pathways.
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