期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 17, 期 -, 页码 1304-1322出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3988
关键词
STIM1; Orai; CRAC; Activation; Permeation; Gating; Inactivation; Review
资金
- Hertha-Firnberg [T466]
- Austrian Science Foundation (FWF) [P22747, P22565]
- Austrian Science Fund (FWF) [P22565, T466, P22747] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 22565] Funding Source: researchfish
Ca2+ release-activated Ca2+ channels mediate a sustained Ca2+ influx following depletion of endoplasmic reticulum stores. This signalling cascade that triggers T-cell activation or mast cell degranulation involves STIM1, the Ca2+ sensor in the endoplasmic reticulum, and the Ca2+ selective Orai channel in the plasma membrane. This review describes the molecular mechanism (s) governing the STIM1/Orai signalling machinery. Moreover, we provide an overview on additional proteins modulating or interacting with the STIM1/Orai1 system. A structure-function relationship highlights regions within STIM1/Orai proteins contributing to activation, permeation and inactivation of CRAC currents.
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