期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 17, 期 -, 页码 976-983出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3968
关键词
Mitotic Checkpoint; Chromatin Remodeling; Sgo1; mitosis; Bub1; Review
资金
- US Public Service [CA090658, CA113349]
- HIEHS [ES000260, ES010344]
In order to maintain chromosomal stability during cell division, eukaryotic cells have evolved a number of surveillance mechanisms termed checkpoints. These checkpoints monitor the completion of essential molecular and cellular processes of one stage before entering another. The spindle checkpoint watches the bi-orientation attachment of spindle microtubules to all condensed chromosomes before initiation of nuclear division during mitosis. Histones are subject to a number of post-translational modifications during the cell cycle, which may in turn modify or facilitate cell cycle progression. Recent studies suggest that mitotic proteins including Bub1 and Sgo1 that are involved in the spindle checkpoint also play a major role in the regulation of histone modifications and chromatin remodeling. This mini-review summarizes emerging information about the new role of spindle checkpoint proteins in chromatin remodeling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据