4.5 Article

Omega-3 polyunsaturated fatty acids in the brain: metabolism and neuroprotection

期刊

FRONTIERS IN BIOSCIENCE-LANDMARK
卷 16, 期 -, 页码 2653-2670

出版社

FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3878

关键词

DHA; ischemia; Alzheimer's disease; Parkinson's disease; Review

资金

  1. Natural Science of Foundation of China [30870794, 81020108021]
  2. NIH [NS062157, NS056118, NS036736]

向作者/读者索取更多资源

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are a group of essential fatty acids that serve as energy substrates and integral membrane components, and therefore play crucial roles in the maintenance of normal neurological function. Recent studies show that n-3 PUFAs display neuroprotective properties and exert beneficial effects on the cognitive function with aging. The brain's need of n-3 PUFAs is predominantly met by the blood delivery due to their limited synthesis in the brain. The present review focuses on the metabolism of n-3 PUFAs in the brain, including their accumulation and turnover. We also highlight the current understanding of the neuroprotective effects of n-3 PUFAs against cerebral ischemia and neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

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