期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 16, 期 -, 页码 2259-2270出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3852
关键词
Molecular Biology; Cancer Biology; Hedgehog signaling; GLI; RAS; KRAS; signaling crosstalk; Review
资金
- DFG
- LOEWE (Tumor Inflammation)
Both RAS and Hedgehog (HH) pathway activation can be found in approximately one third of all cancers. In many cases, this activation occurs in the same tumor types, suggesting a positive impact of a simultaneous activation of RAS and HH on tumor development. This review aims to summarize the current knowledge about the molecular and functional crosstalk of RAS and HH signaling in the development of hyperproliferative disease.
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