期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 16, 期 -, 页码 458-471出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3698
关键词
Hydrogel; hyaluronan; MSCs; Aragonite; Calcite; Review
Stem cell development and fate decisions are dictated by the microenvironment in which the stem cell is embedded. Among the advanced goals of tissue engineering is the creation of a microenvironment that will support the maintenance and differentiation of the stem cell - based on embryonic and adult stem cells as potent, cellular sources - for a variety of clinical applications. This review discusses some of the approaches used to create regulatory and instructive microenvironments for the directed differentiation of mesenchymal stem cells (MSCs) using three-dimensional crystalline calcium carbonate biomaterials of marine origin combined with a hydrated gel based on hyaluronan.
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