期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 15, 期 -, 页码 166-179出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3613
关键词
CAFs; Cancer; Microenvironment; Review
资金
- NCI NIH HHS [R01 CA129000, R01 CA124650-03, R01 CA129000-03, R01 CA124650] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA129000, R01CA124650] Funding Source: NIH RePORTER
Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor microenvironment which promotes the growth and invasion of cancer cells by various mechanisms. CAFs demonstrate a high degree of heterogeneity due to their various origins; however, many distinct morphological features and physiological functions of CAFs have been identified. It is becoming clear that the crosstalk between the cancer cells and the CAFs plays a key role in the progression of cancer, and understanding this mutual relationship would eventually enable us to treat cancer patients by targeting CAFs. In this review, we will discuss the latest findings on the role of CAFs in tumorigenesis and metastasis as well as potential therapeutic implication of CAFs.
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