期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 15, 期 -, 页码 883-900出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3652
关键词
RPA; phosphorylation; DNA replication; DNA repair; DNA Damage Response; Checkpoint Activation; Review
资金
- American Cancer Society [ACS RSG-06163-01-GMC, ACS RSG-10-031-01-CCG]
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.
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