期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 13, 期 -, 页码 1447-1471出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2774
关键词
dendrimers; nanocarrier; non-steroidal anti-inflammatory drugs; anti-microbial drugs; anti-viral drugs; anti-cancer drugs; review
Dendrimers are new artificial macromolecules which have the structure like a tree. They are hyperbranched and monodisperse three-dimensional molecules with defined molecular weights, large numbers of functional groups on the surface and well-established host-guest entrapment properties. Recently, dendrimers have successfully proved themselves as promising nanocarriers for drug delivery because they can render drug molecules a greater water-solubility, bioavailability, and biocompatibility. In this review, recent progress in the pharmaceutical applications of dendrimers as delivery systems for drugs, paticularly, the non-steroidal anti-inflammatory, anti-microbial/anti-viral and potent anticancer drugs is discussed. Three possible interaction mechanisms between dendrimers and drug molecules are presented. In addition, the pharmacodynamic and pharmacokinetic properties of both dendrimer/drug complex and dendrimer-drug conjugation after their administration to animals are evaluated.
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